Dr. Grenga Genetic Testing Methylation Genetic Testing

Methylation Genetic Testing

In recent years, genetic testing has soared in popularity, becoming a crucial tool for those seeking to enhance their health through personalized medicine. The spotlight on genetic testing has grown especially bright following high-profile discussions, like the one Joe Rogan had with Gary Brecka, where the potential of genetic insights to revolutionize personal health was vividly highlighted. One of the key focuses of this conversation was methylation and its profound impact on our health—a topic that is both complex and promising.

Understanding Methylation

Methylation is a biochemical process involving the transfer of a methyl group onto amino acids, proteins, enzymes, and DNA in every cell and tissue of our body. This process is critical for numerous bodily functions such as detoxification, energy production, and the synthesis of neurotransmitters. Methylation helps control the expression of genes, enabling our bodies to adapt to our environment by turning genes on and off based on our current needs, which is crucial for optimal health.

However, when methylation is impaired, it can lead to a multitude of health issues. Impaired methylation has been linked to diseases ranging from cardiovascular disease to neurodegenerative disorders and cancer. This makes understanding one’s methylation processes through genetic testing not just informative but potentially life-altering.

What is Genetic Methylation Testing?

Genetic methylation testing analyzes your DNA to identify variations and mutations in specific genes that are crucial for the methylation process. Such tests focus on identifying single nucleotide polymorphisms, or SNPs, which are the most common type of genetic variation among people. Some of these genetic variations can significantly impact how well your methylation pathways function.

At Anchored in Health, we recognize the power of this testing. It provides deep insights into an individual’s genetic predispositions, which can influence their risk of chronic illnesses and their general well-being. Methylation tests measure the ability of your body to undergo methylation effectively and can reveal specific nutritional deficiencies that may be impeding this process.

Who Should Consider Methylation Genetic Testing?

This type of testing is invaluable for individuals experiencing symptoms across a broad spectrum, including:

  • Cardiovascular diseases
  • Mood and psychiatric disorders such as depression, anxiety, or bipolar disorder
  • Detoxification challenges, particularly those related to exposure to toxins or heavy alcohol consumption
  • Persistent fatigue and cognitive decline
  • Increased cancer risk

Understanding your methylation status can also benefit those without current health issues but who are interested in preventive health measures to maintain long-term wellness.

Personal Insights: The Practical Benefits of Methylation Testing

I decided to undergo genetic methylation testing after struggling with unexplained fatigue and mood swings. The results were eye-opening. They revealed I had a variation in the MTHFR gene, affecting my body’s ability to process folate efficiently, which is vital for proper methylation.

Armed with this information, I worked with a functional medicine doctor to adjust my diet and supplement intake, specifically increasing my intake of B-vitamins and methyl-folate. Over time, these adjustments led to noticeable improvements in my energy levels and overall mood stability.

The 10X Health Test and Beyond

While many home testing kits are available, such as those from 23andMe, these often do not provide detailed methylation analysis. The methylation test recommended by Gary Brecka on the Joe Rogan podcast, offered by 10X Health, is priced at $599 and specifically tests for critical methylation SNPs, including MTHFR, MTR, MTRR, and COMT.

At Anchored in Health, we utilize the 3×4 Genetics Testing, which goes a step further by analyzing 157 SNPs, providing a comprehensive view of genes affecting not only methylation but also other vital processes like detoxification, inflammation, mood, cognition, and metabolism. This test, priced at $395, offers an extensive profile that aids in creating a highly personalized treatment plan.

Is Genetic Methylation Testing Worth It?

The value of genetic methylation testing lies in its application. Simply taking a test without implementing changes based on its results will likely yield little benefit. However, when used to tailor a personal health plan, it can profoundly impact your health and quality of life.

Working with a knowledgeable healthcare provider to interpret these results and develop a targeted action plan is crucial. This approach ensures that any nutritional deficiencies and genetic predispositions are addressed, paving the way for improved health outcomes.


Methylation genetic testing offers a window into the unique workings of your body at a molecular level, providing critical insights that can help tailor personal health strategies. For those willing to take the next step in their health journey, understanding and optimizing methylation through genetic testing could be the key to unlocking a healthier future.

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